This book constitutes revised selected papers from the refereed proceedings of the 15th Colombian Congress on Advances in Computing, CCC 2021, held in Bogotá, Colombia, during November 22–26, 2021.The 8 full papers and 2 short papers included in this book were carefully reviewed and selected from 47 submissions. They were organized in topical sections as follows: Artificial intelligence; educational informatics; and information systems.