Syphilis is an illness with mythology. The story of its origin, dissemination and treatment have all been mired in confusion, a mix of reality and quackery. I have tried to put the organism as the principal protagonist of the story, firmly in an historical focus which centres more on its social impact than on its particular medical management. A diagnosis of Syphilis had personal and community consequence and its impact transcended into the arts. Despite the discovery of an effective treatment to which the organism has fortunately failed to mutate, the restrictions in available management...