This book constitutes revised selected papers from the thoroughly refereed proceedings of the 10th International Conference on Analysis of Images, Social Networks and Texts, AIST 2021, held in Tbilisi, Georgia, during December 16–18, 2021.The 20 full papers and 5 short papers included in this book were carefully reviewed and selected from 118 submissions. They were organized in topical sections as follows: Invited papers; natural language processing; computer vision; data analysis and machine learning; social network analysis; and theoretical machine learning and optimization.