The unique tissues of human teeth, enamel, and dentin have been studied by scientists to understand their structure, physical and chemical properties, and the developmental machinery behind these extraordinary properties. During the developmental process, genetic, and environmental factors or the interplay between them may cause defects in dental hard tissues, impairing their biology and function. These defects have long been studied to provide better dental care and to find novel treatment options. Understanding the mechanical, chemical, and structural differences in developmental dental...