In this issue of Clinics in Geriatric Medicine, guest editors Edward Schneider and Brandon K. Koretz bring their considerable expertise to the topic of polypharmacy. Provides in-depth reviews on the latest updates in polypharmacy, providing actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.