"Design Engineering for Industry 4.0 (DE4.0) represents the 'human-cyber-physical view of the systems realization ecosystem “that is necessary to accommodate the drivers of Industry 4.0 (IoX) and provide an open ecosystem for the realization of complex systems. Seamless integration of digital threads and digital twins throughout the product design, the development and fulfillment lifecycle; the ability to accommodate diverse and rapidly changing technologies; and the mechanisms to facilitate the creation of new opportunities for the design of products, processes, services, and systems are...