The content of the book collects some contributions related to the talks presented during the INdAM Workshop "Fractional Differential Equations: Modelling, Discretization, and Numerical Solvers", held in Rome, Italy, on July 12–14, 2021. All contributions are original and not published elsewhere.The main topic of the book is fractional calculus, a topic that addresses the study and application of integrals and derivatives of noninteger order. These operators, unlike the classic operators of integer order, are nonlocal operators and are better suited to describe phenomena with memory (with...