This book constitutes the refereed proceedings of the 18th International Conference on Information Security and Cryptology, Inscrypt 2022, held in Beijing, China during December 11–13, 2022.The 23 full papers and 3 short papers included in this book were carefully reviewed and selected from 68 submissions. They were organized in topical sections as follows: Block Ciphers, Public key Encryption & Signature, Quantum, MPC, Cryptanalysis,Mathematical aspects of Crypto, Stream ciphers, Malware, Lattices.