This book constitutes the refereed proceedings of the 13th International Conference on Software Business, ICSOB 2022, which was held during November 8-11, 2022 in Bolzano, Italy. The special theme of ICSOB 2022 was “Software for Digital Transformation”.The 19 full papers together with 6 short papers presented were carefully reviewed and selected from 53 submissions. The conference is covering different aspects of Digital Transformation, Software Startups, Software Ecosystems, Software Processes, Platform Economy, Software Sustainability, and People and Process Analytics.