This proceedings, ICMTEL 2022, constitutes the refereed proceedings of the 4thInternational Conference on Multimedia Technology and Enhanced Learning, ICMTEL 2022, held in April 2022. Due to the COVID-19 pandemic the conference was held virtually.The 59 revised full papers have been selected from 188 submissions. They were organized in topical sections as follows: internet of things and communication; education and enterprise; machine learning; big data and signal processing; workshop of data fusion for positioning and navigation; and workshop of intelligent systems and control.