This brief focuses on introducing a novel mathematical framework, referred as hypergraph theory, to model and solve the multiple interferer scenarios for future wireless communication networks. First, in Chap. 1, the authors introduce the basic preliminaries of hypergraph theory in general, and develop two hypergraph based polynomial algorithms, i.e., hypergraph coloring and hypergraph clustering. Then, in Chaps. 2 and 3, the authors present two emerging applications of hypergraph coloring and hypergraph clustering in Device-to-Device (D2D) underlay communication networks, respectively, in...