This handbook has been designed to provide a comprehensive and state-of-the art review and update of the major issues and challenges specific to fine needle aspiration (FNA) and small tissue core biopsies, which have emerged as primary modalities in establishing a definitive cancer diagnosis in the field of anatomic pathology, both in the U.S. and worldwide. Making an accurate diagnosis from a limited sample can be quite challenging yet crucial to patient care. The handbook, using the most current and evidence-based resources, will 1) emphasize a triple test (clinical, radiologic, and...