Herpesviruses are widely distributed in nature, causing disease in organisms as diverse as bivalves and primates, including humans. Each virus appears to have established a long-standing relationship with its host, and the viruses have the ability to manipulate and control the metabolism of host cells, as well as innate and adaptive antiviral immune responses. Herpesviruses maintain themselves within hosts in a latent state resulting in virus persistence for years - usually for the life span of the hosts. Herpesviruses comprise a large number of pathogens with diverse cellular targets and...