The first edition of this book was the seminal book on pharmaceutical extrusion, focusing on extrusion as a manufacturing methodology for dosage forms. In the past 10 years, extrusion has become an accepted technology to continuously mix active pharmaceutical ingredients with excipients. This acceptance has resulted in many hardware and process advancements which have been highlighted in this second edition. The book brings together all extrusion related technical information necessary for the development, manufacturing, and marketing of pharmaceutical dosage forms.

This book is open access under a CC BY 4.0 license.

CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease.

This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.