This book constitutes the refereed proceedings of two workshops held at the 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016, in Athens, Greece, in October 2016: the First Workshop on Large-Scale Annotation of Biomedical Data and Expert Label Synthesis, LABELS 2016, and the Second International Workshop on Deep Learning in Medical Image Analysis, DLMIA 2016. The 28 revised regular papers presented in this book were carefully reviewed and selected from a total of 52 submissions. The 7 papers selected for LABELS deal with topics from the...