An ultimate drug should be easily synthesized possessing high level of target activity, chemical stability, minimum side effects and good penetration property. Mainly it should be non toxic and posses satisfactory pharmacokinetic properties. In this chapter improved optimization in drug-target interactions can be done using various design strategies i.e. improving pharmacokinetic properties of the drugs. Design strategies which improve the interaction by increasing the ability of the drug to reach its desired site of action, with increased lifetime are mainly focused. The ability of the drug...

Since past five years the chemical medicinal applications of combinatorial chemistry was revised in the particular succession. The field has developed considerably. Firstly the capability of making large chemical libraries having great informational macromolecules for conceptive screening determinations was quiet considerate and prominent. Currently this phenomenon has directed to other way with the cognizance that only a subset of the organic molecules which have the ability to produce has a genuine chance of developing to oral drugs. combinatorial chemistry emerged out of peptid3e chemistry...