A daring, kaleidoscopic novel about the clash of empires and ideas, told through a tennis match in the sixteenth century between the radical Italian artist Caravaggio and the Spanish poet Francisco de Quevedo, played with a ball made from the hair of the beheaded Anne Boleyn.

The poet and the artist battle it out in Rome before a crowd that includes Galileo, a Mary Magdalene, and a generation of popes who...