This doctoral thesis focuses on the search for new phenomena in top-antitop quark (tt) final states with additional b-quark jets at the LHC. It uses the full Run 1 dataset collected by the ATLAS experiment in proton-proton collisions at s=8 TeV. The final state of interest consists of an isolated lepton, a neutrino and at least six jets with at least four b-tagged jets, a challenging experimental signature owing to the large background from tt+heavy-flavor production. This final state is characteristic of ttH production, with the Higgs boson decaying into bb, a process that allows direct...