The purpose of the work was to Compare the hepatoprotective activity of Acanthospermum hispidum ethanolic extract and herbal niosomal suspension against hepatotoxicity. AHEE and HNS were investigated against hepatotoxicity produced by administering a combination of four anti-tubercular drugs isoniazid, rifampin, pyrazinamide and ethambutol for the period of 28 days by oral route in rats.AHEE and HNS were administered along with 1 hr prior administration of ATDs once daily to five groups of Albino Wistar rats weighing about 150-200 g. Silymarin was used as a standard drug. Liver biomarkers...