This book covered DNA based chemistry of purine nucleoside with novel heterocycles to find out a new target for cancer agents. It gives a quick access to summarise chemistry of purine behalf of the other nucleosides for any researchers. On this summarised study, we can find a novel scaffold which may gives better life to human beings.It is mainly focused on click chemistry on purine base particularly with triazole ring, both of these coupled and give active molecules among with other available anti-cancer agents.