It is obvious from the present study findings that, a positive Semmes-Weinstein Monofilament (SWM) test result is a significant and independent predictor of future foot ulceration or likely of future lower extremity amputation as well in patients with diabetes mellitus. Therefore SWM test is an important evidence-based tool for predicting the prognosis of patients with diabetic foot, thus enabling improved patients selection for early intervention and management. SWM test can assist practitioner in tailoring care to prevent unnecessary complications and suffering, as well as reduce costs.