Alzheimer's disease (AD) is the most common cause of dementia in the elderly and is characterized by a progressive memory decline, impairments in language and visual spatial skills, impairments in behavior, resulting in a loss of independence, reduction of quality of life, and ultimately death. In the present study, we have described a facile synthesis of novel promising anti-Alzheimer's disease steroidal curcumin derivatives and investigated the importance of incorporating heterocylic moiety to the curcumin nucleus to form new effective hybrid molecules All the tested compounds have been...