Hepatocellular carcinoma is a major health problem worldwide, with an estimated incidence ranging between 500,000 and 1,000,000 new cases annually. It is the fifth most common cancer in the world and the third most common cause of cancer-related deaths.For years, partial hepatectomy and liver transplantation have been considered as the main curative treatments. However, only 10% to 20% of HCC are resectable. Anatomic location, size or number of lesions, inadequate liver remnant, or co-morbid condition precludes surgery in the majority of patients. Currently, local ablative therapy competes...