Thrombosis is a major mechanism of cardiovascular disease and is a leading cause of death. Thrombosis generally occurs in the setting of imbalance in haemostatic regulation favoring blood clot formation. Activated protein C (APC) is a naturally circulating anticoagulant protein in plasma, which exerts its effects mainly by breaking down activated factor V in the coagulation cascade. A single point mutation in the coagulation factor V gene (FV R506Q) renders factor V resistant to inactivation by APC. The frequency of this mutation is known to be significantly increased in patients with...