Edentulousness, partial or complete is the most common clinical situation; a dental health care professional is likely to face in his/her clinical practice. Skillfully designed dentures were made as early in middle ages and during this, dentures were seldom considered as a treatment option. They were hand carved and tied in place with silk threads and had to be removed before eating. The primary goal of this review is to aid the practicing dentist in critically analyzing the current literature and in recognizing the hierarchy of evidences available on denture base materials. This scientific...