The present work is an attempt to design mouth dissolving tablets of Ondansetron hydrochloride. Drug Resin Complex was formulated by direct compression into mouth dissolving tablet using microcrystalline cellulose PH 102, as diluent and croscarmalose sodium and sodium starch glycolate as superdisintegrants while aspartame was used as sweetening agent to enhance palatability. Taste masking was done by using polacrilex resin Tulsion 335. The prepared formulation can be useful for patients who have swallowing difficulty.