This book reviews the podophylliotoxin -a plant toxin mainly from podophyllum hexandrum known as mitotic poison. this book covers the present, past and future prospectives of podophilliotoxin and its analogs.its implementation in ayurveda and Chinese system of medicine for the treatment of various aliments including Cancer .The mode of action of podophylliotoxin, its analogs i.e tenopside, etoposide and how these analogs can be modified for higher efficacy. This book will be beneficial for cancer research, research scholars, alternate medicine practitioner, pharmacognosy research .