This study introduce quick, reliable and reproducible prognostic and diagnostic tool for Colorectal and Breast cancer patients coupling serum TGF- 1 level to quantitative gene expression in blood samples. Serum TGF- 1 level previously reported significance as a diagnostic, prognostic and even therapeutic decisive tool is confirmed showing significant correlation to solid tumor type and size. Blood TGF- 1 quantitative gene expression is offered as an easy, quick and reproducible tool ensuring serum TGF- 1 level reliability."