This book constitutes the thoroughly refereed post-workshop proceedings of the Second International Workshop on Hybrid Systems Biology, HSB 2013, held as part of the ECAL 2013 event, in Taormina, Italy, in September 2013; and the Third International Workshop on Hybrid Systems Biology, HSB 2014, held as part of CAV 2014, in Vienna, Austria, in July 2014.

This volume presents 8 full papers together with 2 invited tutorials/surveys from 21 submissions.

The HSB 2013 workshop aims at collecting scientists working in the area of hybrid modeling applied to systems biology, in order...