Cannabidiol (CBD) is a nonpsychoactive component of cannabis with a high potential for use in several therapeutic areas. It binds very weakly to the CB1 and CB2. It has been evaluated both in vitro and in vivo in anti-inflammatory assays. Thus, it lowers the formation of TNF-α, a proinflammatory cytokine, in vitro, and was found to be an oral anti-arthritic therapeutic in murine collagen-induced arthritis in vivo. Its numerous potentially therapeutic pharmacological effects may be due in part to its metabolites. Indeed, a derivative of such a metabolite, CBD-dimethylheptyl...