Fibrosis is a natural healing process and defined by the overgrowth, hardening, and/or scarring of various tissues, and attributed to excess deposition of cellular matrix components including collagen. According to etiological development of fibrosis we proposed two types of fibrosis as follows. The intractable diseases cirrhosis, renal and glomerular sclerosis, scleroderma, interstital pneumonitis, and cystic fibrosis are some of the examples of diseases' related fibrosis that occur in the liver, kidney, skin, lung and serous glands respectively. Recombinant technology is one of the...