Epilepsies and headaches are two sides of the same coin. Studying their relations helps to better understand their mechanisms and plan their treatments. Both are paroxysmal disorders of the brain and have ictal and interictal manifestations sometimes overlapping. It is very important to know that headaches determine a significant worsening in the quality of life of people with epilepsy. That is why epilepsies and headaches do not coexist by chance and are important comorbidities.