Due to the high interest in bioactive plant derived materials, hepatoprotective activity of the hydro-alcohol extract of Gentiana spicata (Gentianaceae) on carbon tetrachloride treated rats was investigated. This plant is common in the tropics and subtropics of both hemispheres. It is commonly used as folk medicine for treating stomach disorders, hypertension, renal colic, rheumatic pains, and for elimination of stones from the kidney and the ureters. Pre-treatment with gentiana extract significantly decreased alanine aminotransferase and aspartate aminotransferase enzymes, the major...