Tumor cells have developed advantages to acquire hallmarks of cancer through cell signaling pathways misregulation. The sequential activation of genes in a pathway is regulated by miRNAs. Loss or gain of miRNA expression could activate o repress a particular cell axis. miRNAs are grouped in clusters with anti-oncomiRs and oncomiRs function that regulate MAPK, PI3K-AKT, NOTCH, proteasome-culling rings, and apoptosis cell signaling. In the progression of cervical cancer there are three well-established steps to reach cancer that we used in the model proposed here. The first step comprises gene...
Tumor cells have developed advantages to acquire hallmarks of cancer through cell signaling pathways misregulation. The sequential activation of genes...