Nasal carriage of Staphylococcus aureus act as endogenous reservoir for clinical infections in the colonized individual but also as a source of cross-colonization for community and hospital spread. Medical students and Health care workers may serve as carriers and victims of Staphylococcus aureus. There is need of continuous surveillance and prompt treatment for Nasal carriage of Staphylococcus aureus. Hospital infection control practices should be strictly followed. Antibiotic abuse should be discouraged.