Many compounds of this group have an acute and moderate chronic toxicity that manifests itself with the frequent introduction of toxic and sublethal doses. The high activity of phosphatases, carboxyesterases and amidases in the organ-isms of warm blooded animals result in the rapid decomposition of organo-phosphorous compounds into non toxic water soluble products which is ex-creted through urine. The dermal toxicity of organophosphorous insecticide is not high but toxicants like methyl-parathion are highly toxic when they get into the skin. Several methods have been used for the...

Various authors defined the term drug in various ways.The most widely accepted definition of the drug is any chemical agent that affects the living process.Further, it can be elaborated as the chemical and medicine meant for treatment,mitigation or prevention of diseases in human beings or animals for internal or external use.All substances other than food intended to affect the structure or any function of the human or animal body including contraceptives as well as substances used for destruction of vermin and insects,which are causing diseases in human beings or animals.Pharmaceutical...

Pharmaceutical suspensions are uniform dispersions of solid drug particles in a vehicle in which the drug has minimum solubility. These are usually formulated to improve chemical stability of drug, mask the unpleasant taste. Deferiprone, Deferoxamine, Deferasirox are most commonly used iron chelating agents.

Oral drug delivery is the most desirable and preferred method of administering therapeutic agents for their systemic effects. In addition, the oral medication is generally considered as the first avenue investigated in the discovery and development of new drug entities and pharmaceutical formulations mainly because of patient acceptance, convenience in administration, and cost-effective manufacturing process. For many drug substances, conventional immediate-release formulations provide clinically effective therapy while maintaining the required balance of pharmacokinetic and pharmacodynamic...

The aim of present study is to design and develop a solid oral extended release dosage form (tablet) of Niacin to deliver controlled release of drug at desired site at specific time comparable to the innovator product with better stability, high production feasibility, and excellent patient compatibility. The objective of the study is to evaluate the release pattern of the drug from fabricated extended release tablets and compare with marketed sample of the same drug Niaspan 1000mg ER tablet over a period of 24 hours. To carry out the stability for the optimized formulations.

The laboratory study was conducted to evaluate the persistence of Spirotetramat 240 SC (w/v) in sandy loam, loamy sand, sandy clay and clay soils. T0 - Untreated Control T1 - Spirotetramat 240 SC (w/v) @ 0.05 mg/L T2 - Spirotetramat 240 SC (w/v) @ 1.0 mg/L Collected the composite soil sample from 0-15 cm depth 2 hours (0 day) after the application. Continued the sampling on 1 3, 5 and 7 days for Spirotetramat and its BYI 08330 enol metabolite. All the samples were analysed for spirotetramat content by a validated HPLC-UV method with an acceptable mean recovery of spirotetramat; 92% for Sandy...

Oral drug delivery is the most desirable and preferred method of administering therapeutic agents for their systemic effects. In addition, the oral medication is generally considered as the first avenue investigated in the discovery and development of new drug entities and pharmaceutical formulations, mainly because of patient acceptance, convenience in administration, and cost-effective manufacturing process. For many drug substances, conventional immediate-release formulations provide clinically effective therapy while maintaining the required balance of pharmacokinetic and pharmacodynamic...