In medical and pharmaceutical field, the necessity of tailor made drug delivery system has attained significant attention. This suggests that we should take a lead in the area of drug delivery systems. Clay is viable to drug delivery systems, and is expected to provide sustained release characteristics as well as enhanced mechanical properties owing to their layered structure. One of the clay that is montmorillonite act as an adsorbs dietary toxins, bacterial toxins associated with gastrointestinal disturbance, hydrogen ions in acidosis, and metabolic toxins such as steroidal metabolites...