Meloxicam (MLX) is a highly potent, non - steroidal anti - inflammatory drug (NSAID), is used for the treatment of rheumatoid arthritis, osteoarthritis and other joint diseases. However, the gastrointestinal tract (GI T) adverse effects, such as stomachache, indigestion, and patient compliance are weaknesses the oral and injectable MLX administrations. MLX poor water solubility can give rise to many formulation problems that reduce s its therapeutic efficiency and bioavailability. The objective of this study was to develop a transdermal gel formulation of MLX microsponges in order to enhance...