A series of 11 curcumin analogues were subjected to molecular properties prediction and drug likeness by Molinspiration and MolSoft software, lipophilicity and solubility parameters using ALOGPS 2.1 program. The compounds followed the Lipinski "Rule of five" were synthesized for anti-HIV screening as oral bioavailable drugs/leads. Further the structure of the synthesized compounds was confirmed by spectral analyses (IR, NMR and mass) and the compounds (3a-k) were evaluated for anti-HIV activity as per the standard protocol. Maximum drug-likeness model score (1.1.0) was found for...

A series of 11 oxadiazole analogues were subjected to molecular properties prediction and drug likeness by Molinspiration and MolSoft software, lipophilicity and solubility parameters using ALOGPS 2.1 program. The compounds followed the Lipinski "Rule of five" were synthesized for antimicrobial screening as oral bioavailable drugs/leads. Further the structure of the synthesized compounds was confirmed by spectral analyses (IR, NMR and mass) and the compounds (4a-k) were evaluated for antibacterial and antifungal activities as per the standard protocol....

A series of seven nateglinide analogues were synthesized successfully using 4-isopropyl cyclohexyl carboxylic acid (trans acid) as starting material, react with thionyl chloride and formed trans-4-isopropyl cyclohexane carbonyl chloride (trans acid chloride) as an intermediate which further reacted with D-phenylalanine to yield nateglinide. The derivatives were synthesized by reacting nateglinide and ethylchloroformate, and formed an unstable mix anhydride compound, which further react with primary and secondary amines to yield the nateglinide derivatives. All these molecules were...