The aim of the study was to prepare and evaluate floating in-situ gel of methotrexate to increase the gastric residence time resulting in sustained drug release in gastrointestinal tract. Methotrexate is anticancer drug. It shows the undesirable side effect due to their fast release in the gastrointestinal tract (GIT). Floating in situ gel was prepared by using in-situ gel forming polymers like sodium alginate and pectin. Drug-excipients compatibility was carried out by FT-IR study. A 3level 2factor full factorial design was applied to investigate the combined effect of sodium alginate...