Salmonella is a Gram-negative facultative intracellular anaerobe causing typhoid fever (enteric fever) in humans. Fluoroquinolones and carbapenems are the drug of choice against Salmonella. Emergence of resistance against these drugs makes Salmonella, a very lethal pathogen. Fluoroquinolone resistance mechanisms include target gene mutations, active efflux pump, decreased outer membrane permeability and plasmid-mediated resistance. Recently, there is an emergence of beta-lactam resistance in the Salmonella which involve expression of beta-lactamases, presence of efflux pump, alterations in...