The use of environmental and nutritional factors to optimize fermentation conditions, are important for application of bioprocesses. To optimize these processes using conventional techniques, for example the one factor at a time method, is time consuming and laborious. Statistical design of experiments has become popular for medium optimization in industry since this allows the investigator to assess more than one factor at a time. This method is a time saving and effective method for the screening significant factors of a multivariable system. This book reviews the latest research on...