Curcumin is a phenolic pigment obtained from powdered rhizomes of Curcuma longa Linn. (Family: Zinziberaceae). Curcumin is the main active constituent of C. longa L. It is imperative to know the different size of their rhizomes which contain the highest quantity of main three active constituent (curcumin, desmethoxycurcumin and bisdesmethoxycurcumin). A Validated UPLC-MS/MS method has been developed for the isolation and quantification of three main curcumin in different sizes of rhizomes of C. longa and C. amada collected from market. The proposed method is simple, precise, specific,...