Hepatic encephalopathy(HE)is a severe complication of cirrhosis that is related to the effect of excess ammonia.The present study was constructed to investigate the potent role of L-carnitine, -lipoic acid either individually or in combination in management of hepatic encephalopathy in adult male rats. The aim of this study was extended to elucidate the most effective therapy against experimental hepatic encephalopathy. The present results revealed that the treatment with lactulose, L-carnitine, -lipoic acid or a combined dose of L-carnitine and -lipoic acid resulted in pronounced improvement...