Chronic hepatitis C virus (HCV) infection is an important public health issue. Globally, the estimated prevalence of hepatitis C virus infection is about 3% where Egypt is the country with the highest HCV prevalence in the world. Interferon based therapies are the leading therapeutic regimens to hepatitis C infection worldwide. Different regimens of IFN therapy have variable response rate as sustained virological response (SVR), relapser (response and relapse) (RR) or breakthrough (BT), and non-response (NR). Combination therapy of interferon and ribavirin or pegylated interferon had...