Leukemia, a blood or bone marrow cancer, is the seventh most common cancer in humans of all ages with the highest incidence among children aged 14 year or less. In the United States, an estimated 48,610 new leukemia cases with 23,620 deaths were reported in 2013. Among these fatalities were children, comprising of 30% of the cases. ZERUMBONE, the natural predominant compound in the rhizome of Zingiber Zerumbet, has poor water-solubility. We have developed the ZERUMBONE loaded nanostructured lipid carrier by high pressure homogenization technique. The ZERUMBONE-NLC was shown to have anticancer...

The Zingiberaceae family of plants is found in tropical and subtropical areas and approximately 161 species from 18 genera of this family are found in Peninsular Malaysia. The plant species belonging to the Zingiberaceae family have been reported to possess biological activities responsible for its medicinal value. The ginger rhizome is generally recognized as safe and it is used traditionally in local folklore medicine for various ailments. Zingiber zerumbet (L.) Smith belonging to this family is an edible ginger, originating from South-East Asia and been cultivated for thousands of years....

Zerumbone (ZER) is a naturally occurring dietary compound, present in many natural foods consumed today. The compound derived from several plant species of the Zingiberaceae family that has been found to possess multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory and anticancer activities. However, evidence of efficacy is sparse, pointing to the need for a more systematic review for assessing scientific evidence to support therapeutic claims made for ZER and to identify future research needs. This review provides an updated overview of in vitro and in...