Systematically constructing an optimal theory, this monograph develops and explores several approaches to Hardy spaces in the setting of Alhlfors-regular quasi-metric spaces. The text is divided into two main parts, with the first part providing atomic, molecular, and grand maximal function characterizations of Hardy spaces and formulates sharp versions of basic analytical tools for quasi-metric spaces, such as a Lebesgue differentiation theorem with minimal demands on the underlying measure, a maximally smooth approximation to the identity and a Calderon-Zygmund decomposition for...