Holothuria arenicola is the most important and abundant sea cucumber species in the Mediterranean Sea on the Egyptian coast. The problems associated with antifibrotic drugs are chronic administration, the reduced therapeutic effects and toxicity, so developing antifibrotics from natural products may reduce the risk of toxicity and maintain the therapeutic effectiveness when they used clinically. The therapeutic use of sea cucumbers for healing is established, where they used for joint pain, tendonitis and sprains. The present prospective study correlated the antifibrotic effect of HaE to its...

Marine organisms are a wonderful source of biologically active natural products. Sea cucumbers are among the marine organisms which use as traditional food, especially in Asia. They are cylinder-shaped invertebrates that live in a variety of sea floor habitats from warm tropical waters to cold deep-sea trenches. Holothuria atra is the most important and abundant sea cucumber species in the Red Sea on the Saudi Arabia coast. Sea cucumber contains physiologically active phenolic compounds with antioxidant activity, which afforded a potential therapeutic activity against hepatorenal diseases.

Natural Products traditionally have played an important role in drug discovery and were the basis of most early medicines. Marine organisms are a wonderful source of biologically active natural products. The Sepia ink has been proved to be an alternative medicine and has a wide range of therapeutic applications. In our book we tried to discover the therapeutic activity of cuttlefish ink against the liver fibrosis.