Stroke is the third most common cause of death and has profound negative social and economic effects. The failure, of various clinical trials of exogenously administered drugs as potential stroke therapy has enhanced the ongoing search to identify endogenous mechanisms activated after cerebral ischemia that might be harnessed as neuroprotectants in stroke. Postconditioning (PoCo), is an adaptive technique, whereby brief repetitive cycles of ischemia with intermittent reperfusion immediately following prolonged ischemia elicits tissue protection. Protective role of PoCo has been reported in...