Neuroendocrine Cell Hyperplasia of Infancy (NEHI) is a rare diffuse lung disease, providing diagnostic and prognostic difficulties due to heterogeneous presentations and unknown etiology. Confirmed cases of NEHI show an increased count of neuroendocrine cells in airway walls upon completion of a lung biopsy. These cells are associated with branch morphogenesis during fetal growth, which leads our hypothesis that NEHI symptoms are correlated with changes in infant airway tree structure. Using volumetric computed tomography scans, patient airway trees are edited to establish a skeletonized...